Automated extraction process and LDTD-MS/MS analysis of Tetrahydrocannabinol (THC) and Cannabidiol (CBD) in leaves.
Consult the document
Optimization of the parameters of the new LDTD ion source, Axino, for direct analysis of drugs of abuse in saliva.
Optimization of the parameters of the new LDTD ion source for analysis of explosives.
Design of a new gas focusing system for Laser Diode Thermal Desorption ionization source.
Xylazine, also know as tranq or zombie drug, is a new muscular relaxant widely used to adulterate drugs on the street.
Cortisol analysis is used as biomarker of hypothalamic-pituitary-adrenal (HPA) activity associated to physiological stress. Cortisol is slowly and continuously incorporated into growing hair.
The SAMHSA drug panel was established to evaluate the presence of the most common drugs of abuse and their metabolites in biological matrices. The panel contains stimulants such as cocaine and amphetamines, depressants such as opiates and opioids, and perturbators such as PCP.
Introduction Over the last 10 years, the quantitation of immunosuppressive drugs has been subject to continuous improvements in analytical methods to optimize cost, time, and accuracy of results. The transition from immunoassay to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) has significantly improved all these criteria but has not reduced the analytical time below […]
Rivaroxaban is an anticoagulant used to prevent thromboembolism. Prompt quantification of this drug in a patient’s bloodstream is important to avoid overdoses and to adjust their medication.
Since the hair root is vascularized during its growth, illicit drugs present in the blood stream may enter the hair shaft via the root where they will be sequestered.
The rapid quantification of cortisol in saliva can be useful for the screening of adrenal pathologies like Cushing’s syndrome. Saliva analysis of cortisol can be use as biomarker for stress assessment. It was shown that salivary cortisol can provide important information about hypothalamic-pituitary-adrenal (HPA) axis activity under normal and stress conditions.
Vitamin A (Retinol) and E (Tocopherol) have important roles in physiological functions to maintain good health.
In various industrial production plants, workers can be exposed to organic compounds like toluene, xylene and styrene. The chronic exposure to these compounds has been linked to severe impacts on the central nervous system.
Vitamin C (Ascorbic acid, AA) is an important compound that engages in many physiological activities in living organisms (synthesis of collagen, acts as an antioxidant, metabolisms and synthesis of adrenaline, prevention, and treatment of scurvy and cold).
Introduction Ethyl glucuronide is a direct metabolite of ethanol and is formed by the enzymatic conjugation of ethanol with glucuronic acid. Alcohol is normally detected for only a few hours, whereas ethyl glucuronide (ETG) can be detected in the urine for 1 to 3 days. The creatinine concentration in urine is screened to verify the […]
Serotonin is an indoleamine molecule that is derived from the amino acid tryptophan. Its biological function is complex, and it impacts multiple aspects in our lives, such as our mood, our memory, and even undesirable effects such as vomiting.
Yeasts mediums have a wide range of applications in the food industry, biomass production, biofuel industry and in the heterologous production of compounds. Literature data shows different applications for yeasts as a biocatalyst.
The rapid quantification of cystine in urine can be useful for the detection of cystinuria, an autosomal recessive disorder. Newborn screening for this disease can be performed by thin layer chromatography. Cystinuria is characterized by the formation of cystine kidney stones.
In forensic sciences, explosives analysis of swabbed surfaces is used in crime scene investigation. Jagerdeo et al1 report a rapid screening method for explosives analysis using LDTD® technology for forensic application. The Environmental Protection Agency (EPA) developed Method 8330B (SW-846) for the analysis of explosives in different matrices (water, soil or sediment) using a HPLC-UV method.
Vitamin K1 (Phylloquinone) is an important compound that plays a key role in the synthesis of several blood coagulation factors, in bone metabolism and in vascular calcifications.
During the last few decades, research work has been done to investigate the different drugs of abuse in different types of biological samples (urine, saliva, hair, etc). One of the advantages of hair sample is the noninvasive collection.
In 2019, the US Department of Health and Human Services (via the SAMHSA agency) has established scientific and technical guidelines for federal workplace drug testing programs in oral fluids (Federal Register / Vol. 84, No. 207, 2019).
Toxicological labs need to screen different drugs classes like benzodiazepines, anxiolytics and anticonvulsants using a generic sample preparation and fast analytical technique.
Introduction Impaired driving is a public health and safety concern. Toxicological testing is a critical part of these investigations. Academy standards board (ASB) published a guideline of the minimum requirements for target analytes and analytical sensitivity (ANSI/ASB standard 120, 1st Ed. 2021). Samples from these investigations are sent to crime labs, however, the analysis time […]
The analysis of nail clippings is a great alternative to hair analysis, in the case where hair is not available. They provide up to 6 months of drug usage history and are easily collected for testing.
Busulfan (Bu) is an alkylating agent commonly used in patients being prepared for hematopoietic stem cell transplantation (HSCT) for various types of hematologic malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) in addition to non-malignancies (thalassemia). In the clinical doses, Bu is considered as a potent cytotoxic drug which causes severe and prolonged myelosuppression.
The rapid quantification of estrone in serum can be useful to monitor estrogen levels and help explain abnormal menstrual cycles, symptoms of menopause, abnormal or heavy bleeding, infertility or any other hormonal alterations.
Acople o Luxon Ion Source® ao seu espectrômetro de massa Sciex e obtenha tempo de varredura inferior a 1 segundo.
Couple the Luxon Ion Source® to your Sciex mass spectrometer and attain an analysis runtime of less than 1 second. This apparatus is the second-generation sample introduction and ionization source based on the LDTD® technology for mass spectrometry.
Acople o Luxon Ion Source® ao seu espectrômetro de massa Shimadzu e obtenha tempo de varredura inferior a 1 segundo.
Couple the Luxon Ion Source® to your Thermo Scientific™ mass spectrometer and attain an analysis runtime of less than 1 second.
Couple the Luxon Ion Source® to your Shimadzu mass spectrometer and attain an analysis runtime of less than 1 second.
