Quantification of PFAS in Plasma: a Faster Way to Monitor Human Exposure

Introduction

Since the 1950s, Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been used in many consumer products and industrial processes. There are thousands of types of PFAS. The most common types and final products of degradation are PFOA (perfluorooctanoic acid) and PFOS (perfluorooctanoic sulfonic acid). They are widely detected in different environmental media and human blood. The National Health and Nutrition Examination Survey (NHANES) and European Food Safety Authority (EFSA) suggest guidelines with concentration ranges for PFAS exposition. The sum of the major PFAS between 2-20 ng/mL detected in human plasma can be a potential risk for adverse health effects which increase with concentrations greater than 20 ng/mL. To quickly monitor PFAS exposure levels in human plasma, LDTD-MS/MS is a useful tool.

Presented at ASMS 2025.