Free Estrone in Serum

Authors: Serge Auger, Pierre Picard and Jean Lacoursière
Themes: High-Throughput, Serum, LDTD-MS/MS
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Introduction

The rapid quantification of estrone in serum can be useful to monitor estrogen levels and help explain abnormal menstrual cycles, symptoms of menopause, abnormal or heavy bleeding, infertility or any other hormonal alterations.

Our goal for this application note is to develop a diagnostic tool to rapidly quantify estrone in serum, which will allow the rapid diagnosis of abnormal disorders.

LDTD®-MS/MS offers specificity combined with an ultra-fast analysis for an unrivaled quantification method. To develop this application, we focused on performing an efficient sample preparation, which will increase the speed of the analysis process and confirm diagnoses more quickly.