FAQ Series: How Many Analytes Can We Analyze Within the Same Sample with the Luxon Ion Source®?

FAQ Series: How Many Analytes Can We Analyze Within the Same Sample with the Luxon Ion Source®?

Even though the Luxon Ion Source® is used in conjunction with mass spectrometers, we know that it is a disruptive technology. Because it is so unique and goes so much faster than the technologies on the market, we are often asked similar questions.

This week, we are answering the following question: How Many Analytes Can We Analyze Within the Same Sample with the Luxon Ion Source®?

Contrary to a method such as Immunoassay, using the Luxon Ion Source® with a mass spectrometer does not require the use of a multitude of reagents in order to analyze multiple analytes in one sample.

The number of analytes that the a Luxon-MS system can analyze will depend on the method and on the mass spectrometer you are working with.

For example, if you are working with a triple quadrupole using MRM transitions and a very quick desorption, up to 60 transitions can be analyzed at a time.

In high-resolution mode, the number is much higher: you can analyze a mixture of up to 200 standards at a 500 nM concentration.

For untargeted assays, using the high-resolution mode again, there is no limit to the number of molecules that can be monitored at the same time.

However, a mix of highly concentrated compounds should be avoided – this will overload the plate and cause ion suppression, which is not wanted when using this technique.

You have questions you would like us to answer? Not sure how the Luxon Ion Source® can help you with your applications?

Contact us!