FAQ Series: How does the LDTD-APCI sensitivity compares to that of ESI?

If you missed last week’s question, we were answering a pretty common one: How long does it take to clean the source, and how many parts are involved?
You can read it by clicking here!

This week, we are getting a bit deeper on the technical aspects of the Luxon Ion Source®.

We often get asked: How does the LDTD-APCI (dry) sensitivity compares to that of ESI?

In the LDTD® process, we work in an environment where there is no solvent and no mobile phase. When the desorption occurs, the analyte is thermally desorbed from the LazWell plate and is carried as a gas when it enters the APCI region. In this case, the APCI gas is dry air at normal pressure and temperature, which results in a protonation efficiency superior to that of traditional LC-APCI. The absence solvent allows to obtain approximately 92% analysis success rate for the whole process, in the small-molecule range, similar to that of ESI.

Every day, our chemists work on attaining even higher success rates to suit our clients’ needs.

The LDTD-APCI sensitivity is actually much higher than with LC-APCI, where, for the latter, there is an interaction between the samples and the solvents which causes unwanted charge transfers. 

So, to recap, LDTD-APCI is comparable in sensitivity to ESI, without the unwanted matrix effect and no memory effect!

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