CERTUS FLEX: Automating Your Sample Preparation

In recent years, automation has been a major concern for several laboratories in very different fields: pharmaceutical, clinical, toxicology, cosmetics, environmental, food, ect. Many of these laboratories have turned to high footprint robots to fill their needs. Although these have many uses (mixing, cooling, heating, washing, …),they can be an overkill solution to a simple problem: automating your liquid dispensing. The CERTUS FLEX from Fritz Gyger is a small-footprint, highly-accurate and precise liquid dispenser that can be customized to fill the user’s needs.

Here are a few applications for this system.

  1. Calibration curve aliquots preparation

Analytical laboratories have to prepare several calibration curves for their sample analysis: large volumes of each concentration are made and transferred into smaller vials. Using a CERTUS FLEX liquid dispenser from Fritz Gyger, an automated procedure for calibration curve preparation or aliquots was developed. Three solutions are used: a stock solution of the standard used, a dilution solution and a matrix solution. For more information on this application: see AN_1706.

  1. 5 to 10 mL dilutions in vials

Pharmaceutical laboratories use methods that contain several dilutions of collected samples. These dilutions can become tedious when done on a high number of samples and it leaves the methods vulnerable to high margins of error. Using an automated liquid dispenser to perform these dilutions would greatly improve the reproducibility as well as reduce the time taken to go through this process. For more information on this application: See TN_1801

  1. Calibration curve spotting (0.1 to 10 µL)

Certain technologies, such as the LDTD® and the Luxon Ion Source®, analyze minuscule sample volumes (0.1 to 10 µL) deposited on sample holder plates. Spotting several replicates of calibration curves or depositing the same sample dozens of times can cause results with low precisions or accuracy. Using an automated liquid dispenser to perform these depositions would greatly improve reproducibility. For more information on this application: See TN_1802

  1. Small volume derivatization on well plate

Mass spectrometry is considered as the best analytical technique for sensitive and specific measurements. Nevertheless, in screening assays, the throughput must be sufficiently high to keep the cost and time in a reasonable range for the pharmaceutical laboratories.  Assays with amino acid markers pose a difficulty for a thermal desorption technique as their volatility is limited. The CERTUS FLEX system from Fritz Gyger was used to dispense the liquids onto the LazWell plate, thus diminishing the margin of error attached to manual preparation. For more information on this application: See AN_1704

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